Another really Hard work is behind us !
This time, thanks to the grant obtained from the Jakub Hr. Potocki Foundation, we managed to conduct research on new prognostic factors in patients with brain gliomas who underwent radiotherapy.
Big congratulations to the entire team!
Below is a summary of our most important results!
Gliomas are the predominant cause of cancer-related deaths among the young population. Even after incorporating IDH1/2 mutations and 1p19q codeletion, there are doubts regarding adjuvant treatment in WHO G2/G3 gliomas. miRNA molecules control about 30% of all genes, as well as many oncogenes, tumor suppressor genes, and genes responsible for the response to ionizing radiation and systemic treatment. Patients with brain gliomas exhibit miRNA disorders. We aimed to evaluate the
expression of miR-200 family members in relation to selected clinicopathological factors and their prognostic value.
It was shown that miR-200a-3p, miR-200a-5p, miR-200c-5p, miR-141-3p, and miR-429 can be independent predictors of survival. Better 2- and 5-year OS was associated with higher expression of miR-200a-3p, miR141-3p and lower expression of miR-200a-5p, miR-200c-5p, miR-429.
The strongest predictors of survival were miR-200a-5p, miR-200b-3p, miR-200c-5p, miR-141-3p, miR-429, tumor volume and CTV. Members of the miR-200 family exhibit prognostic value for 2- and 5-year OS.
Presented predictive models of survival may be clinically valuable for treatment optimization.